Interaction Between Gold Nanoparticles and ssDNA

Chem. J. Chinese Universities

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Interaction Between Gold Nanoparticles and ssDNA

SUN Li-Ping^1*, ZHANG Jian-Feng¹, LI Hui¹, WANG Xiu-Yan¹, ZHANG Zhao-Wu¹, WANG-Shuang¹, ZHANG Qi-Qing^1,2*

1. Research Center of Biomedical Engineering, College of Materials, Xiamen University, Technology Research Center of Biomedical Engineering of Xiamen, Key Laboratory of Biomedical Engineering of Fujian, Xiamen 361005, China;
2. Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China

Received:2008-04-22 Revised:1900-01-01 Online:2009-01-10 Published:2009-01-10
Contact: SUN Li-Ping, ZHANG Qi-Qing

Abstract

Abstract: The interaction between unmodified gold nanoparticles and single-stranded DNA (ssDNA) was studied at different pH value. And the sequence-dependent stability of ssDNA-GNPs complex was investigated. GNPs precipitated from red colloid solution in the form of aggregation after alkalization with NaOH or dissolve after acidification with HCl. Both processes were irreversible. If the same particles were incubated with ssDNA, ssDNA-GNPs complex were stable against NaOH-induced aggregation at pH=12.6, and aggregated at pH=1.4, while redispersed at pH=12.6. It was concluded that unmodified GNPs could be coated by unmodified ssDNA, which protected GNPs dispersing in solution at pH=12.6, and prevented GNPs from dissolving at pH=1.4, as measured by TEM and UV-Vis absorption spectrum. The bindig affinities of oligonucleotides to GNPs were different in the order of poly dA>poly dC>poly dT. Moreover, longer ssDNA had stronger protective effect to gold nanoparticles. HCl-induced GNPs aggregation could be an effective method to identify the diversity of deoxyribonucleotides in ssDNA sequences.

Key words: Gold nanoparticle, Single-stranded DNA, Interaction, ssDNA

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SUN Li-Ping^1*, ZHANG Jian-Feng¹, LI Hui¹, WANG Xiu-Yan¹, ZHANG Zhao-Wu¹, WANG-Shuang¹, ZHANG Qi-Qing^1,2*. Interaction Between Gold Nanoparticles and ssDNA[J]. Chem. J. Chinese Universities, doi: .

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Interaction Between Gold Nanoparticles and ssDNA

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