Chem. J. Chinese Universities ›› 2016, Vol. 37 ›› Issue (2): 224.doi: 10.7503/cjcu20150662
• Articles: Inorganic Chemistry • Previous Articles Next Articles
JIN Xintian1,2, LIU Gang2, LI Junzhe2, SUN Lili2, WANG Junrong2, LI Junfeng3, LI Pei2, CHEN Wenqing2, WANG Qiang2, TONG Ti1,*(
)
Received:2015-08-20
Online:2016-02-10
Published:2016-01-13
Contact:
TONG Ti
E-mail:TTi666@163.com
CLC Number:
TrendMD:
JIN Xintian, LIU Gang, LI Junzhe, SUN Lili, WANG Junrong, LI Junfeng, LI Pei, CHEN Wenqing, WANG Qiang, TONG Ti. Preparation of Hyaluronic Acid-modified Mesoporous Silica-coated Gold Nanorods and Their Application in Chemo-Photothermal Therapy of Cancer[J]. Chem. J. Chinese Universities, 2016, 37(2): 224.
Scheme 1 Synthetic routes of the multifunctional drug delivery system(hyaluronic acid-modified mesoporous silica-coated gold nanorods) and the mechanism of chemo- and photothermal therapy
Fig.1 Schematic illustration of CD44 receptor-mediated endocytosis of nanoparticles and subsequent chemotherapy and NIR-induced hyperthermia
Fig.2 TEM images of AuNR@SiO2(A) and AuNR@SiO2-HA(B, C)
Fig.3 Absorption spectra(A) of AuNR@SiO2(a), AuNR@SiO2-HA(b) and Dox-AuNR@SiO2-HA(c) and FTIR spectra(B) of AuNR@SiO2-NH2(a) and AuNR@SiO2-HA(b)
Fig.4 Zeta potential of AuNR@SiO2(a), AuNR@SiO2-NH2(b) and AuNR@SiO2-HA(c)
Fig.5 Hydrodynamic diameters of AuNR@SiO2 and AuNR@SiO2-HA
Fig.6 Photothermal curves of H2O and AuNR@SiO2-HA under NIR laser irradiation as a function of time
Fig.7 Thermographs of H2O(a) and AuNR@SiO2-HA(808 nm, 1.8 W/cm2, 8 min)(b) mea-sured by infrared thermal imaging camera
Fig.8 Drug release profiles from Dox-AuNR@SiO2-HA at different conditions
Fig.9 Confocal laser scanning microscopy investigation of the localization of AuNR@FITC-SiO2-HA to MDA-MB-231 cells (A) Blue fluorescence from nuclear stain DAPI; (B) green fluorescence from AuNR@FITC-SiO2-HA;(C) bright-field image; (D) combined image of (A) to (C).
Fig.10 Flow cytometry analysis of uptake efficiency of nanoparticles by MDA-MB-231(A) and NIH-3T3(B) cells Red: AuNR@FITC-SiO2; green: AuNR@FITC-SiO2-HA.
Fig.11 In vitro viability of MDA-MB-231 cells in the presence of AuNR@SiO2-HA and Dox-AuNR@SiO2-HA
Fig.12 In vitro viability of NIH-3T3 cells in the presence of AuNR@SiO2-HA and Dox-AuNR@SiO2-HA
Fig.13 In vitro viability of MDA-MB-231 cells in the presence of Dox-AuNR@SiO2-HA with or without laser irradiation
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