Chem. J. Chinese Universities

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Monitoring of Solid-phase Synthesis of 7-Fluoro-2H-1,4-benzoxazine-3(4H)-ones via FTIR Spectroscopy

HUANG Ming-Zhi1,2, CHEN Wei-Min1, HUANG Ke-Long3, HUANG Lu2, YANG Guang-Fu1   

    1. Department of Chemistry, Central China Normal University, Wuhan 430079, China;
    2. National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410007, China;
    3. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • Received:2005-10-13 Revised:1900-01-01 Online:2006-11-10 Published:2006-11-10
  • Contact: YANG Guang-Fu

Abstract: The solid-phase synthesis of 7-fluoro-1,4-2H-benzoxazine 3(4H)-ones on Wang resin via esterification, etherification, reduction, cyclization and cleavage reactions was studied, and the reaction conditions were optimized after analyzing the reaction kinetics according to the IR spectrum.

Key words: Combinatorial chemistry, Solid-phase organic synthesis, Infrared spectroscopy

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