Chem. J. Chinese Universities

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A New Triterpene from Akebia Quinata Stem

LIU Gui-Yan1, MA Shuang-Cheng2, ZHENG Jian2, YU Zhen-Xi2, LIN Rui-Chao2   

    1. School of Life Science & Technology, Beijing Institute of Technology, Beijing 100081, China;
    2. National Institute for the Control of Pharmaceutical & Biological Products, Beijing 100050, China
  • Received:2005-10-24 Revised:1900-01-01 Online:2006-11-10 Published:2006-11-10
  • Contact: LIN Rui-Chao

Abstract: To study the chemical constituents, the ethanol extract of dried stem of Akebia quinata(Thunb.) Decne. was seperated by dichloromethane, n-butanol in sequence. The n-butanol extract was further isolated by D101 macroporous resin and silica gel column chromatography. A new triterpene with two known triterpenes were isolated, their structures were identified as 3α,24-dihydroxy-30-norolean-12,20(29)-dien-28-oic acid (Ⅰ), 3α,24,29-trihydroxyolean-12-en-28-oic acid (Ⅱ), 2α,3β,23-trihydroxyolean-12-en-28-oic acid (Ⅲ). The new compound Ⅱ was nominated as quinatic stem acid. The structures were identified and elucidated by physicochemical properties and spectral analysis.

Key words: Akebia, Akebia quinata(Thunb.)Decne., Triterpene, Quinatic stem acid

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