Microdomain Structure and Dynamics of Poly(L-alanine)-b-poly (ethylene glycol) Monomethyl Ether Diblock Coploymer Characterized by High Resolution Solid-state NMR

Abstract

Abstract: The microdomain structure of poly(L-alanine)-b-poly(ethylene glycol)monomethyl ether, MPEG-PLA, used as a new amphiphilic diblock copolymer was characterized by proton spin diffusion experiments with ¹³C detection and ¹ Hwideline separation 2D¹H, ¹³CNMR experiment(WISE-NMRspectroscopy).The MPEG chains could form crystalline as well as amorphous phases, but the degree of crystallinity is considerably lower in the diblock polymer compared with MPEGhomopolymer.And the PLAblocks are very rigid as α-helix and β-sheet forms.The results imply that the region of α-helix forms is quite larger than β-sheet forms.

Key words: Block copolymer, Microdomain, Solid-state NMR

CLC Number:

O631

TrendMD:

WU Guo-Lin, SUN Ping-Chuan, MA Jian-Biao . Microdomain Structure and Dynamics of Poly(L-alanine)-b-poly (ethylene glycol) Monomethyl Ether Diblock Coploymer Characterized by High Resolution Solid-state NMR[J]. Chem. J. Chinese Universities, 2003, 24(8): 1515.

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Microdomain Structure and Dynamics of Poly(L-alanine)-b-poly (ethylene glycol) Monomethyl Ether Diblock Coploymer Characterized by High Resolution Solid-state NMR

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