Synthesis and Characterization of p-tert-Butylcalixarene Derivative Containing Adenine and Its Molecular Recognition to Nucleotides and Bases

Chem. J. Chinese Universities

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Synthesis and Characterization of p-tert-Butylcalixarene Derivative Containing Adenine and Its Molecular Recognition to Nucleotides and Bases

ZHANG Hai-Yan², SHI Hui-Jie¹, SHI Xian-Fa^1*

1. Department of Chemistry, Tongji University, Shanghai 200092, China;
2. College of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China

Received:2007-12-26 Revised:1900-01-01 Online:2008-09-10 Published:2008-09-10
Contact: SHI Xian-Fa

Abstract

Abstract: A new adenine-containing derivative of p-tert-butylcalixarene(AC)5,11,17,23-tetra-t-butyl-25,27-bihydroxy-26-(1-(9-adenineyl)-propoxy)-28-bromopropoxycalixarene was synthesized and characterized via IR, EA, ¹H NMR and ESI-MS spectra. The molecular recognition of AC to different nucleotides and bases was studied via UV-Vis method: the absorbance of mixed systems with different concentrations or components was measured. The results show that AC can selectively bond with uracil and uridine from other nucleotides and bases, which means AC can recognize uracil and uridine.

Key words: Calixarene derivative, Adenine, Molecular recognition, UV-Vis spectrum

CLC Number:

O629
O641.3

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ZHANG Hai-Yan², SHI Hui-Jie¹, SHI Xian-Fa^1*. Synthesis and Characterization of p-tert-Butylcalixarene Derivative Containing Adenine and Its Molecular Recognition to Nucleotides and Bases[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and Characterization of p-tert-Butylcalixarene Derivative Containing Adenine and Its Molecular Recognition to Nucleotides and Bases

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