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Transport and Absorption of Chiral Metal Complexes d-[Co(EDTA)]- and l-[Co(EDTA)]- Across Caco-2 Cell Monolayers

MU Yong-Ping1, WU Gang1,4*, QIAO Xiu-Wen2, GAO Yu-Xi3, ZHOU Li-She1 , HE Yan-Ling4   

    1. Department of Biochemistry and Molecular Biology, Baotou Medical College, Baotou 014010, China;
    2. School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832002, China;
    3. Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;
    4. The Research Institute of Trace Element in Organism, Baotou Medical College, Baotou 014010, China
  • Received:2007-11-02 Revised:1900-01-01 Online:2008-07-10 Published:2008-07-10
  • Contact: WU Gang

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Abstract: The trasport rate of chiral complexes d-[Co(EDTA)]- and l-[Co(EDTA)]- across Caco-2 cell monolayers were measured by the kinetics method. The studies discover that there is an obvious difference about the trasport rate of d-[Co(EDTA)]- and l-[Co(EDTA)]- when they get across Caco-2 cell monolayers because of the chiral difference of the metal complexes. The results show that there is a chiral selectivity when chiral metal complexes were transported and absorbed across Caco-2 cell monolayers and imply that intestine would selectively absorb drugs of chiral metal complexes. The trasport rate of d-[Co(EDTA)]- and l-[Co(EDTA)]- passing through Caco-2 cell monolayers depends on the grads of the complexes concentration, it is shown that their transport model is as simple diffuse when they were transported and absorbed through Caco-2 cell monolayers.

Key words: Chirality, Metal complex, Caco-2 cell monolayer, Transpot, Absorption

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