Preparation of Adsorbents for Oligopeptide and Adsorption Mechanism

Chem. J. Chinese Universities

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Preparation of Adsorbents for Oligopeptide and Adsorption Mechanism

LI Ji-Hong^1,2, ZHANG Yuan-Wei¹, YANG Mei¹, ZHANG Jing¹, MA Yi¹, YUAN Zhi¹*

1. Key Laboratory of Functional Polymer Materials of the Ministry of Education, Institute of Polymer Chemistry Nankai University, Tianjin 300071;
2. College of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China

Received:2007-09-11 Revised:1900-01-01 Online:2008-06-10 Published:2008-06-10
Contact: YUAN Zhi

Abstract

Abstract: Octapeptide VVRGCTWW(V8) is an oligopeptide separated from the blood serum of uremic patients. To remove it, some adsorbents containing phenyl group with different length spacers were prepared. The result of adsorption experiments shows the adsorbent Phe3c had the highest adsorption capacity to V8. Molecular simulation technology and NMR were used to study the adsorption mechanism. The results demonstrate that the phenyl group in ligands could form π-π stack with Trp residue in octapeptide. Moreover, the strength of the interaction between the octapeptide and adsorbents could increase with the growth of the spacer, because the increasing length of spacer could overcome the space hinder. In a conclusion, under the condition of adoption of reasonable molecular models, the molecular docking could be used to virtually screen the adsorbents for oligopeptide, and to study the adsorption mechanism.

Key words: Oligopeptide, Adsorbent, Ligand, Adsorption mechanism, Virtual screening

CLC Number:

O629.7
O631

TrendMD:

LI Ji-Hong^1,2, ZHANG Yuan-Wei¹, YANG Mei¹, ZHANG Jing¹, MA Yi¹, YUAN Zhi¹*. Preparation of Adsorbents for Oligopeptide and Adsorption Mechanism[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Adsorbents for Oligopeptide and Adsorption Mechanism

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