Preparation and Binding Properties in Aqueous Media of Cholic Acid Imprinted Polymers

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (8): 1727.

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Preparation and Binding Properties in Aqueous Media of Cholic Acid Imprinted Polymers

XU Zhi-Feng^1*, KUANG Dai-Zhi¹, WEN Ge², ZHANG Fu-Xing¹, WANG Jian-Qiu¹, LI Jun-Hua¹

1. Department of Chemistry and Material Science, Key Laboratory of Functional Organometallic Materials of College of Hunan Province, Hengyang Normal University, Hengyang 421008, China;
2. Unisplendour Guhan Group Hengyang Chinese Medicines Corporation Limited, Hengyang 421003, China

Received:2010-10-11 Revised:2010-11-01 Online:2011-08-10 Published:2011-07-19
Contact: XU Zhi-Feng E-mail:xuzhifenghw@163.com
Supported by:
湖南省高校“十一五”重点建设学科资助项目和衡阳师范学院科研基金(批准号: 2006B04)资助.

Abstract

Abstract: In order to achieve effective imprinting in aqueous media, a cholic acid imprinted polymer (MIP1) was prepared by the combined use of bismethacryloyl-β-cyclodextrin (BMA-β-CD) and 2-(diethylamino) ethylmethacrylate (DEAEM) as functional monomers. The recognition ability of MIP1 for the template in aqueous media was evaluated by equilibrium binding experiments. The results indicated that the imprinted polymer MIP1 obviously exhibited a higher selectivity for cholic acid than the cholic acid imprinted polymers (MIP2 and MIP3) using only BMA-β-CD or DEAEM as a functional monomer. The specific binding capacity (ΔCP) and imprinting factor (IF) of MIP1 were 38.81 μmol/g and 2.46, respectively. It demonstrated that the combination of hydrophobic effect and electrostatic interaction in molecular imprinting was essential for the improvement of the selective ability of the imprinted polymer in aqueous media. In addition, hydrophobic effect was confirmed to be the important force for driving the template molecules into the cavities created by the imprinting process.

Key words: Molecular imprinting, Cholic acid, β-Cyclodextrin, Binding specificity, Hydrophobic effect

CLC Number:

O657.3

TrendMD:

XU Zhi-Feng*, KUANG Dai-Zhi, WEN Ge, ZHANG Fu-Xing, WANG Jian-Qiu, LI Jun-Hua. Preparation and Binding Properties in Aqueous Media of Cholic Acid Imprinted Polymers[J]. Chem. J. Chinese Universities, 2011, 32(8): 1727.

References

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Preparation and Binding Properties in Aqueous Media of Cholic Acid Imprinted Polymers

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