Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (6): 1312.

• Articles • Previous Articles     Next Articles

Synthesis and Biological Activities of Derivatives of 3,6-Diphenoxymethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

SUN Xiao-Hong1*, BAI Yan1, LIU Yuan-Fa2, CHEN Bang2, JIA Ying-Qi2   

  1. 1. College of Chemical Engineering, Chemical Research Institute, 
    2. Department of Chemistry, Northwest University, Xi’an 710069, China
  • Received:2010-07-19 Revised:2010-11-15 Online:2011-06-10 Published:2011-05-10
  • Contact: SUN Xiao-Hong E-mail:xhsun888@sohu.com
  • Supported by:

    国家自然科学基金(批准号:  21073141)资助.

Abstract: 4-amino-2,4-dihydro-5-(phenoxymethyl)-3-mercapto-3H-1,2,4-triazole and substituted phenoxyacetic acid refluxed in POCl3 to afford 3,6-diaryloxymethene -1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles. The chemical structures of the compounds were confirmed by 1H NMR, IR and elemental analysis. The preliminary toxicity testing of all the target compounds were investigated. The results showed that they exhibited melt fungicidal activities.

Key words: Triazole, Thiadiazole, Biological activity

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