Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (5): 1083.

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Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases

TAN Ping¹, YU Ai-He¹, YAN Jing², MI Yong-Sheng², LI Jun-Zi³, XIANG Jian-Nan^2,3,4*

1. Department of Biologic and Chemical Engineering, Hunan Mechanical and Electrical Polytechnic College, Changsha 410151, China;
2. College of Chemistry and Chemical Engineering,
3. Bio-medicine Engineering Center,
4. State Key Laboratory of Chem/Biosensing and Chemometrics, Hunan University, Changsha 410082, China

Received:2010-07-13 Revised:2010-09-20 Online:2011-05-10 Published:2011-04-11
Contact: XIANG Jian-Nan E-mail:jnxiang@hnu.cn
Supported by:
湖南省科技厅计划项目(批准号: 2009FJ3082)资助.

Abstract

Abstract: Ferrocene derives have many special properties. In order to evaluate cytotoxic activity of ferrocene Schiff base, six novel ferrocene Schiff bases were synthesized through the reaction of ferrocene carboxaldehyde with 3-substituted-4-amino-1,2,4-triazole-5-thione and four new ferrocene acylhydrazone Schiff bases were also synthesized with ferrocenecarboxaldehyde or acetylferrocene with acylhydrazine. Its structure were characterized by 1H NMR，IR , MS and Element analysis. their cytotoxic activities were determined in vitro by an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using human cervical cancer cells (Hela). The results indicated that these compounds exhibited some cytotoxic activities against cancer cells. The mechanism of this useful property of these compounds should be conformed in the future.

Key words: Ferrocenecarboxaldehyde, Triazole, Acylhydrazine, Schiffbase, Cytotoxicactivity

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TAN Ping, YU Ai-He, YAN Jing, MI Yong-Sheng, LI Jun-Zi, XIANG Jian-Nan*. Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases[J]. Chem. J. Chinese Universities, 2011, 32(5): 1083.

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Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases

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