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Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (4): 891.

• Articles • Previous Articles     Next Articles

A Natural Cyclic Peroxide Echinobithiophene A with Anti-Microbial from Echinops ritro L.

LI Liang-Bo1,2,  REN Jie1, LAI Ren3, CHENG Zheng-Ming4, ZHU Hua-Jie1*   

  1. 1.  State Key Laboratory of Phytochemistry and Plant Resources of West of China,  Kunming Institute of Botany, Chinese Academy of Sciences,  Kunming 650204,  China; 
    2.  Graduate School of Chinese Academy of Sciences,  Beijing 100049,  China;
    3.  Kunming Institute of Zoology,  Chinese Academy of Sciences,  Kunming 650200,  China;
    4.  Xinjiang Institute of Ecology and Geography,  Chinese Academy of Sciences,  Urumqi 830011,  China
  • Received:2010-05-26 Revised:2010-08-26 Online:2011-04-10 Published:2011-03-09
  • Contact: ZHU Hua-Jie E-mail:hjzhu@mail.kib.ac.cn
  • Supported by:

    国家“九七三”计划项目(批准号: 2009CB522300)、国家自然科学基金(批准号: 30770235,  30873141)、中国科学院基金(批准号: YZ-06-01)和中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室基金(批准号: P2008-ZZ17)资助.

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Abstract: The genus Echinops(Compositae) consists of ca. 120 species in the world.  This genus is represented by 17 species mainly distributed in northwestern area of China. E. ritro L. has only been found in Xinjiang and is used as a remedy for different ailments in Uighur Pharmacopeia instead of E. grijissi Hance.  Echinobithiophene A(1),  a new peroxide bithiophene with a six-membered ring,  was isolated from the ethyl acetate fraction of Echinops ritro L., and its structure was identified by spectral analysis including 2D NMR,  and comparison of optical rotation values and chemical shifts of 13C NMR between the predicted and experimental data. Compound 1 showed significant anti-microbial activity.

Key words: E.ritro L, Echinobithiophene A, anti-bacteria, Optical rotation values, DFT.

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