Effect of Composition on Physical\|chemical Properties and Biological Properties of Hydroxyapatite/Aliphatic Polyurethane Scaffolds for Bone Tissue Engineering

Abstract

Abstract: Aliphatic polyurethane (PU) and hydroxyapatite (HA) composite scaffolds were prepared by in-situ polymerization and gas self-foaming process. The morphologies and properties of the scaffolds were studied by varying the content of HA, foaming agent (water) and soft/hard segment ratio and characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and mechanical test. The results showed that the compressive strength of the scaffolds increased with both the HA content and the hard segment content. The scaffold porous structure was affected by HA content and foaming agent. The scaffold porosity increased with HA content and decreased with the hard segment content. The average pore size of the scaffold also increased with the content of foaming agent. MTT results and SEM observation of cells showed that the porous structure of HA/PU scaffold provided a good microenvironment for cell adherence, growth and proliferation. After implantation in rat muscle, the scaffold was well tolerated by host tissues. The porous HA/PU scaffold provides a good perspective for designable tissue-engineering scaffolds.

Key words: Bone tissue engineering scaffold; , Hydroxyapatite, Aliphatic polyurethane, Effect of composition, Biological property

TrendMD:

WANG Li, ZUO Yi*, ZOU Qin, LI Yu-Bao. Effect of Composition on Physical\|chemical Properties and Biological Properties of Hydroxyapatite/Aliphatic Polyurethane Scaffolds for Bone Tissue Engineering[J]. Chem. J. Chinese Universities, 2011, 32(10): 2453.

References

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