Synthesis and Anti-tumor Activity of Opened A-Ring Modified 18β-Glycyrrhetinic Acid Derivatives

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (9): 1762.

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Synthesis and Anti-tumor Activity of Opened A-Ring Modified 18β-Glycyrrhetinic Acid Derivatives

HU Jun¹, WU Yang¹, ZHAO Chang-Qi², JU Yong^1,3*

1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China;
2. School of Life Science, Beijing Normal University, Beijing 100875, China;
3. State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, China

Received:2009-12-15 Online:2010-09-10 Published:2010-09-10
Contact: JU Yong. E-mail: juyong@mail.tsinghua.edu.cn
Supported by:
国家自然科学基金(批准号: 20772071, 20972086) 和高等学校博士学科点基金(批准号: 20090002110060)资助.

Abstract

Abstract: Glycyrrhetinic acid, a facile pentacyclic triterpenoid with rigid and chiral structures, is widely present in the form of aglycone or glycosides in medicinal plants, which is used as bioactive component on anti-inflammatory, anti-viral and anti-tumor-promotion effect. Owing to its relative low-toxicity, biocompatibility and bioactivity, a series of novel opened A-ring and different functional group derivatives of glycyrrhetinic acid was synthesized by chemical methods. The preliminary biological activities were tested against human liver carcinoma(HepG-2) cell in vitro. The results show that the activity should be affected by the number and the position of hydroxyls.

Key words: 18β-Glycyrrhetinic acid, Triterpenoids, Anti-tumor activity

TrendMD:

HU Jun, WU Yang, ZHAO Chang-Qi, JU Yong*. Synthesis and Anti-tumor Activity of Opened A-Ring Modified 18β-Glycyrrhetinic Acid Derivatives[J]. Chem. J. Chinese Universities, 2010, 31(9): 1762.

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Synthesis and Anti-tumor Activity of Opened A-Ring Modified 18β-Glycyrrhetinic Acid Derivatives

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