Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (9): 1724.

• Articles • Previous Articles     Next Articles

Synthesis of Cytidine-bonded Porphyrins and Their Interaction with Bovine Serum Albumin

JIANG Guo-Fang1*, GAO Feng1, ZHANG Man-Sheng2, LIU Chang1, GUO Can-Cheng1   

  1. 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;
    2. Hunan Public Security College, Changsha 410138, China
  • Received:2008-12-11 Online:2009-09-10 Published:2009-09-10
  • Contact: JIANG Guo-Fang. E-mail: guofangjiang@yahoo.com.cn
  • Supported by:

    国家自然科学基金(批准号: 20502005)、湖南省重点科技项目(批准号: 2008GK2023)和湖南大学重点基金(批准号: 521101787)资助.

Abstract:

Cytidine-bonded porphyrins 6 and 8 were designed and synthesized on the basis of porphyrin′s photosensitivity, special affinity for tumor cells, nucleosides′ antitumor and anticancer activities. Molecular structures of all synthesized compounds were characterized by 1H NMR, IR, UV-Vis, MS and elemental analysis. The interaction between cytidine-bonded porphyrins 6, 8 and bovine serum albumin(BSA) was investigated by fluorescence spectrum. The results show that the novel cytidine-bonded porphyrins 6 and 8 own a powerful ability of quenching the fluorescence of BSA via static quenching.

Key words: Cytidine; Porphyrin; Bovine serum albumin; Fluorescence spectrum

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