CJCU

Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (9): 1709.

• Articles • Previous Articles     Next Articles

Studies on the Detection of Genotype of Lyme Disease Borrelia Burgdorferi by SPR

YU Dong-Dong1, LIU Yan3, ZHANG Lei2, ZHOU Jian-Guang2*   

  1. 1. Hospital of Zhejiang University, Hangzhou 310027, China;
    2. Research Center for Analytical Instrumentation, Zhejiang University, Hangzhou 310058, China;
    3. Department of Chemistry, College of Chemical Engineering, Dalian University of Technology, Dalian 116024, China
  • Received:2009-05-27 Online:2009-09-10 Published:2009-09-10
  • Contact: ZHOU Jian-Guang. E-mail: jgzhou70@126.com
  • Supported by:

    浙江省重大科技项目(批准号: 2008C01053-5)资助.

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Abstract:

The genotypes(B.afzelii and B.garinii) of Lyme disease Borrelia burgdorferi were detected successfully by surface plasmon resonance(SPR) sensor. The genotypes of Borrelia burgdorferi were confirmed by the dissociation constant(KD), which calculated from the kinetic curves of immuoreaction between Ag and Ab at different concentrations. This method was simple, less time consumption and accurate to identify genotypes of Borrelia burgdorferi in serum of patients.

Key words: Surface plasmon resonance(SPR); Lyme disease; Borrelia burgdorferi genotype

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