Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (8): 1674.

• Articles • Previous Articles     Next Articles

Synthesis and Drug Release Behavior of Thermosensitive Dendrimer Derivatives

WANG Wei1,2, ZHANG Jun1, SU Qu1, WANG Zheng1*   

  1. 1. Pharmaceutics, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;
    2. College of Life Science, Agricultural University of Hebei, Baoding 071001, China
  • Received:2008-12-24 Online:2009-08-10 Published:2009-08-10
  • Contact: WANG Zheng. E-mail: wangzheng2006@tju.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 20674055)和国家大学生创新性实验计划第一批资助.

Abstract:

The thermosensitve polymer was grafted to the polyamidoamine(PAMAM) dendrimer using EDC•HCl. The structure of the dendrimer derivative was characterized by FTIR and 1H NMR and the mole-cular weight was determined by GPC and 1H NMR, which indicates that the grafted polymer was synthesized successfully. The thermosensitve properties determined by UV-Vis photometer showed that the LCST was changed in different medium. Using indomethacin as a model drug, the behavior of the temperature controlled drug release from this novel polymer derivative have been studied. The results show that the rate of the drug release can be effectively controlled by the surrounding temperature, and the solubility of the drug is also increased. The new drug carrier is desirable to make a great effect in the drug delivery system.

Key words: Dendrimer derivative; Thermosensitive; Solubility; Controlled release

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