Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (8): 1548.

• Articles • Previous Articles     Next Articles

Fabrication of Seamless PMMA Microfluidic Chips with and Without a Glass-fiber Mixer by Controlled in situ Polymerization

WANG Hai1, CHEN Yi1,2*   

  1. 1. Laboratory of Analytical Chemistry for Life Science, Institute of Chemistry, Chinese Academy of Sciences,
    2. Beijing National Laboratory of Molecular Science, Beijing 100190, China
  • Received:2009-03-18 Online:2009-08-10 Published:2009-08-10
  • Contact: CHEN Yi. E-mail: chenyi@iccas.ac.cn
  • Supported by:

    国家“九七三”计划(批准号: 2007CB714504)、国家自然科学基金(批准号: 20628507)和中国科学院重点基金资助.

Abstract:

A new method was established for the fabrication of seamless polymer microfluidic chips. By the method, seamless PMMA microfluidic chips were easily fabricated by in situ polymerization of monomer solution casting on a channel mold temporarily fixed with pieces of fine iron wires by a magnet beneath the polymerizing container. Seamless channels were formed by bonding two pieces of 70%—80% polymerized PMMA slides of which one was preprinted with channels. Glass-fibers-embedded microfluidic mixers have also been fabricated in the same way where a section of about 2 mm glass-fiber bundle was inserted between two wires before casting polymerizing solution. With such a mixer, ideal mixing was easily achieved at Re≥22. This method features easy manipulation and low cost, it fits ordinary chemistry laboratories, requiring no clean room or lithographic facilities.

Key words: In situ polymerization fabrication; Microfluidic chip fabrication; Embedment of glass fibers; Micromixer

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