Rapid Quantitative Detection of Toxic Diethylene Glycol in Toothpaste by Extractive Electrospray Ionization Ion Trap Mass Spectrometry

Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (8): 1533.

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Rapid Quantitative Detection of Toxic Diethylene Glycol in Toothpaste by Extractive Electrospray Ionization Ion Trap Mass Spectrometry

DING Jian-Hua^1,2, YANG Shui-Ping¹, LIU Qing³, WU Zhuan-Zhang¹, CHEN Huan-Wen^1,2*, REN Yu-Lin², ZHENG Jian³, LIU Qing-Jun³

1. College of Chemistry, Jilin University, Changchun 130012, China;
2. College of Chemistry, Biology and Material Science, East China Institute of Technology, Fuzhou 344000, China;
3. Beijing Center for Physical and Chemical Analysis, Beijing 100089, China

Received:2009-02-25 Online:2009-08-10 Published:2009-08-10
Contact: CHEN Huan-Wen. E-mail: chw8868@gmail.com
Supported by:
国家自然科学基金(批准号: 20505003)和北京市财政项目(批准号: XM-00001783050811002)资助.

Abstract

Abstract:

Using ammonium acetate methanol solution(10 μmol/L) as the spray solvent, a novel method based on reactive extractive electrospray ionization(EESI) ion trap mass spectrometry was developed for the rapid determination of diethylene glycol(DEG) in toothpaste products, which are typical colloidal complex samples containing nano-scale particles in matrices. Under the optimized working conditions, DEG formed non-covalently bound complexes with NH₄⁺, Na⁺ and K⁺ rather than the protonated molecules in the mass spectrum. About 0.1 g of the toothpaste products were required for direct sensitive analysis with EESI-MS, the whole procedure was completed within less than 2 min. Furthermore, the qualitative demonstration and quantitative analysis of DEG of the paste products was also done by the EESI-MS and EESI-MS/MS spectra. This method can be used for the rapid and selective determination of low-level DEG in toothpaste products, and it is a useful method for the rapid determination of low-level components in the viscous nano-materials.

Key words: Extractive electrospray ionization; Mass spectrometry; Toothpaste; Diethylene glycol; Rapid detection; Ion/molecule reaction

TrendMD:

DING Jian-Hua, YANG Shui-Ping, LIU Qing, WU Zhuan-Zhang, CHEN Huan-Wen*, ....... Rapid Quantitative Detection of Toxic Diethylene Glycol in Toothpaste by Extractive Electrospray Ionization Ion Trap Mass Spectrometry[J]. Chem. J. Chinese Universities, 2009, 30(8): 1533.

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Rapid Quantitative Detection of Toxic Diethylene Glycol in Toothpaste by Extractive Electrospray Ionization Ion Trap Mass Spectrometry

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