Abstract:

The protected pentasaccharide repeat unit of E.coli O86 O-antigen was successfully synthesized in seven steps and in 21% overall yield through a combination of HClO₄-SiO₂ solid acid catalytic and inverse procedure. Experimental simplicity, high stereoselectivity, low cost, satisfactory yield are major advantages of our approach. The results of the present exploration should be valuable in the preparation of other oligosaccharides.

Key words: E. coli O86 O-antigen, Human blood group B antigen, Oligosaccharide synthesis