Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (10): 1972.

• Articles • Previous Articles     Next Articles

Synthesis and Bioactivities of Novel Indolocarbazole Derivatives

JIANG Cheng1,2, CHEN Su-Ting1,2, YOU Qi-Dong1,2*, LI Zhi-Yu1,2, TANG Wei-Juan2   

  1. 1. Jiangsu Key Laboratory of Carcinogenesis and Intervention,
    2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • Received:2009-02-25 Online:2009-10-10 Published:2009-10-10
  • Contact: YOU Qi-Dong. E-mail: youqidong@gmail.com
  • Supported by:

    江苏省自然科学基金(批准号: BK2005102)资助.

Abstract:

A series of novel indolocarbazole derivatives was designed and synthesized. The solvent was stu-died and the reaction conditions including solvent choice were optimized via easier operations. The cytotoxicities of the 9 target compounds were tested using MTT methods. The results indicate that compounds 4a, 4b, 4d, 4f and 4i show better in vitro activities against HCT116 and P388 than positive control ED-571 did. Particularly, compound 4f is 10 times more potential against P388 than ED-571.

Key words: Indolocarbazole; Anticancer activity; Cytotoxicity activity

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