Abstract: Bulk liquid membrane(BLM) was developed for the resolution of racemic propranolol(PPL), via the formation of complex between (S,S)-di-n-dodecyl tartrate(DDT) and boric acid, the complex was used as chiral the carrier which was preliminarily characterized by calorimetry. The influences of the molar concentration ratio of PPL to DDT and pH in aqueous phase on the resolution performance were investigated. The optimal resolution conditions were obtained. The resolution process was also analyzed by means of kinetics. At last, the primary research law of BLM resolution was obtained. The law shows that the kinetic resolution is demonstrated to be a process of kinetic resolution. Using the higher DDT concentration will be in favor of increasing the flux of enantiomer and enantioselectivity of resolution. pH of aqueous phase has an important influence on BLM resolution. The resolution process was controlled by extraction reaction. The transport of enantiomer across membrane can be described by two consecutive irreversible pseudo first order reactions.

Key words: Bulk liquid membrane, Kinetic resolution, Racemic propranolol