Abstract:

urine plays very important roles in life process, such as metabolism and heredity, while purine nucleosides and nucleotides are the key components of some important co\|enzymes nucleic acids.  Lots of compounds containing purine ring have been developed into drugs in treating cancer, virus infection and vascular disease.  In recent years, nucleic acid chemistry is also developed into a focused field.  And  derivation and selective modification of purine ring have attracted great attention of researchers.  Although N\|benzyl adenine was found to possess a good plant growth regulation (PGR) activity and used in agriculture for a long time, there is much less attention paid on purine ring than other heterocycles in agro\|chemistry field.  In order to study the synthesis and biological activities of multi-substituted purines, new poly\|substituted purine-8-thiones (6) were obtained from 4\|chloro\|5\|nitropyrimidine (3) via  a series of reactions as amination, reduction and cyclization.  After alkylation of compounds 6, 7 and 8 were obtained in high yields.  The preliminary  bioassay indicates that some of compounds  6, 7 and 8 possess moderate herbicidal and anti-TMV activities.

Key words: Poly\, substituted purine-8-thione; 4\, Chloro-5-nitropyrimidines; Synthesis; Biological activity