Research of IFN-encapsulated Liposomes Regulated by Lecithin Characteristics and Preparation Methods

Chem. J. Chinese Universities

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Research of IFN-encapsulated Liposomes Regulated by Lecithin Characteristics and Preparation Methods

WANG Yan^1,2, ZHANG Shui-Hua², LI Yun-Fu², LI Jiu-Li², CAO Shu-Gui

1. Key Laborabory for Medcular Enzymology & Engineering, Ministry of Education, Jilin University, Changchun 130023, China;
2. Shenzhen Neptunus Interlong Bio-technique Holdings Co., LTD, Shenzhen 518054, China

Received:2006-01-17 Revised:1900-01-01 Online:2006-10-10 Published:2006-10-10
Contact: CAO Shu-Gui

Abstract

Abstract: According to the physical and chemical characteristics of interferon and Lecithin, we selected four kinds of lecithin compounds as the liposomal membrane aterials, prepared liposomes by three methods, investigated liposomal shape, size distribution and the entrapment efficiency(EE) for a 60 d period to explore their influence factors of stability. The result shows the liposome made from DMMPC+DPPC+SA by film evaporation method has a good EE and size stability for 2 months. The size range is from 200 nm to 300 nm, the EE range is from 30%—40%.

Key words: Liposome, Interferon, Film evaporation method, Size distribution

CLC Number:

O631

TrendMD:

WANG Yan^1,2, ZHANG Shui-Hua², LI Yun-Fu², LI Jiu-Li², CAO Shu-Gui. Research of IFN-encapsulated Liposomes Regulated by Lecithin Characteristics and Preparation Methods[J]. Chem. J. Chinese Universities, doi: .

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Research of IFN-encapsulated Liposomes Regulated by Lecithin Characteristics and Preparation Methods

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