Novel Potential Myocardial Perfusion Imaging Agent 99mTcN(PNP5)(NOEt)]+

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (6): 1014.

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Novel Potential Myocardial Perfusion Imaging Agent ^99mTcN(PNP5)(NOEt)]⁺

CHU Jin-Feng¹, LI Bin², KONG De-Jing², WANG Xue-Bin², ZHANG Jun-Bo², WANG Jin-Cheng³, MI Hong-Zhi³, ZHAO Jian-Dong³

1. College of Science, Beijing University of Chemical Technology, Beijing 100029, China;
2. Department of Chemistry, Beijing Normal University, Beijing 100875, China;
3. Department of Nuclear Medicine, Beijing Anzhen Hospital, Beijing 100029, China

Received:2005-01-14 Online:2005-06-10 Published:2005-06-10

Abstract

Abstract: [^99mTcN(PNP5)(NOEt)]⁺was prepared through ligand exchange reaction and its radiochemical purity was over 90% measured by TLC and HPLC. The results of charge character and stability studies indicate that [^99mTcN(PNP5)(NOEt)]⁺ is a cation with a good stability. Studies on the biodistribution in mice and SPECT imaging in dog show that ^99mTcN(PNP5)(NOEt)]⁺ possessed a high myocardial uptake and good retention, and high target to non-target ratios, suggesting that it may be a potential myocardial perfusion imaging agent.

Key words: Technetium-99m, Myocardial perfusion imaging agent, Biodistribution

CLC Number:

O615.4

TrendMD:

CHU Jin-Feng, LI Bin, KONG De-Jing, WANG Xue-Bin, ZHANG Jun-Bo, WANG Jin-Cheng, MI Hong-Zhi, ZHAO Jian-Dong. Novel Potential Myocardial Perfusion Imaging Agent ^99mTcN(PNP5)(NOEt)]⁺[J]. Chem. J. Chinese Universities, 2005, 26(6): 1014.

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Novel Potential Myocardial Perfusion Imaging Agent ^99mTcN(PNP5)(NOEt)]⁺

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