Abstract: A new detection method of gastric endoscope samples with promising perspective in clinical application was first proposed in this paper. The identification of stomach cancer, chronic atrophic gastritis and superficial gastritis for a total of 184 gastric endoscope samples was first investigated by using Fourier transform mid-infrared spectroscopy. The spectral characteristics for different classifications of gastric tissues were summarized and correlated with the corresponding pathological results. The experimental results indicated that the changes of molecular composition and structure with various diseases of stomach tissues occur, so the distinct differences were observed among the FTIR spectra of the normal, atrophic gastritis, superficial gastritis and malignant gastric tissues, which were used to classify the diseases and determine the degree of diseases of the gastric endoscope samples. The results demonstrate that FTIR method possesses promising perspective to be developed as a new non-invasive, rapid, accurate and in vivo gastric endoscope detection technique in clinical application.

Key words: Fourier transform mid-infrared spectroscopy, Gastric endoscope, Spectral analysis, Infrared detection