Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage

Chem. J. Chinese Universities ›› 2004, Vol. 25 ›› Issue (6): 1073.

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Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage

XU Li¹, LI Xiang-Lu¹, HUANG Yi-Bing¹, WU Xiao-Xia¹, HOU Rui-Zhen¹, WANG Hua², WANG Na¹, ZHANG Xue-Zhong¹

1. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130023;
2. China-Japan Union Hospital of Jilin University, Changchun 130031, China

Received:2003-05-30 Online:2004-06-24 Published:2004-06-24

Abstract

Abstract: A small molecule peptide Leu-Asp-Tyr-Glu(LDYE) prepared from the enzymatic hydrolysate of zein was tested for its anti-oxidative activities. The effects of LDYE on the turgidity of mitochondria,the fluidity of membrane,the activity of cytochrome C oxidase and ATPase at subcellular level were investigated by using H₂O2/Fe²⁺-induced mitochondria damage model system. It was found that the small peptide exhibited an obvious ability of removing free radicals and protecting the mitochondria from damage by oxidation.

Key words: Corn peptide, Mitochondria, Anti-oxidation activity

CLC Number:

Q514

TrendMD:

XU Li, LI Xiang-Lu, HUANG Yi-Bing, WU Xiao-Xia, HOU Rui-Zhen, WANG Hua, WANG Na, ZHANG Xue-Zhong. Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage[J]. Chem. J. Chinese Universities, 2004, 25(6): 1073.

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Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage

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