Studies on Molecular Recognition of Imidazole Derivatives by Novel Chiral Tyrosine Tetraphenylporphinatozinc Complex

Abstract

Abstract: Two kinds of novel chiral Zn porphyrin complexes were synthesized and characteried by means of elementary analysis, UV-Vis, ¹H NMR. Molecular recognition was studied between hosts and imidazole derivatives. Association constants of Zn(o-BocTyr)TAPP and Zn(p-BocTyr)TAPP with imidazoles increased in the sequence K(2-MeIm>K(Im)>K(N-MeIm)>K(2-Et-4-MeIm). Through circular dichroism spectra and theoretical calculation method, the chang of position in which imidazoles coordinated to host 1 was studied, it is important to study the structral characterization of porphyrin.

Key words: Chiral porphyrinatozine, Imidazole derivatives, Chiral molecular recognition, Circular dichroism spectra, Molecular mechanics

CLC Number:

O641.24

TrendMD:

WANG Shu-Jun, RUAN Wen-Juan, ZHAO Xiao-Jing, NAN Jing, ZHU Zhi-Ang. Studies on Molecular Recognition of Imidazole Derivatives by Novel Chiral Tyrosine Tetraphenylporphinatozinc Complex[J]. Chem. J. Chinese Universities, 2004, 25(5): 908.

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Studies on Molecular Recognition of Imidazole Derivatives by Novel Chiral Tyrosine Tetraphenylporphinatozinc Complex

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