Separation and Structural Determination of Structure of a New Cembranoid Lactone from the Soft Coral of Sarcophyton sp.

Abstract

Abstract: Many cembranes, 14 membered ring diterpenoids, were reported to have antitumor and antimicrobial activities. Soft corals are rich sources of cembrenoid diterpenes. We reported cembrenoids lactones, such as sarcophinone, iso sarcophinone, sarcophine, sartrochine from the species of Sarcophyton in our earlier papers,. In continuation of our studies on the soft coral Sarcophyton , we obtained a new cembranoid lactone, named sarcophydiol(1) from a specimen of Sarcophyton sp . collected around the bay of Sanya, Hainan Island. On the basis of spectroscopic methods, its structure was determined as ( 10S^*,11S^*)₃,7,11α ,15 tetramethyl 10 β,11β dihydroxy cembr 2 E,6E,14(15)Z trien 16,1 olide(1). The bioactivities of compound 1 were under investigating.

Key words: Soft coral, Sarcophyton, Diterpene, Cembranoid

CLC Number:

O629.61

TrendMD:

MA Xiang-Quan, YAN Su-Jun, SU Jing-Yu, ZENG Long-Mei . Separation and Structural Determination of Structure of a New Cembranoid Lactone from the Soft Coral of Sarcophyton sp.[J]. Chem. J. Chinese Universities, 2004, 25(3): 479.

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Separation and Structural Determination of Structure of a New Cembranoid Lactone from the Soft Coral of Sarcophyton sp.

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