Synthesis and Biological Activity of New Phenylsulfonylurea Derivatives

Abstract

Abstract: In order to develop new herbicidal active structures and research the structure-activity relationship, on the basis of the known monosubstituted phenylsulfonylureas with a high activity we designed and synthesized 14 novel sulfonylurea compounds with a single substituting group, such as alkoxy, alkylthio and alkylamino in the pyrimidine ring. The structures of all compounds were confirmed by ¹H NMR spectra data and elemental analysis. Herbicidal activitiy including IC₅₀ was determined by rape root length experiment and pot experiment. The results show that the variation of 4- substituting group of the pyrimidine ring affects the activity of the compounds respectively. Herbicidal activity decreases in the sequence of alkoxy, alkylthio and alkylamino substituent.

Key words: Sulfonylurea, Herbicide, Synthesis, Pyrimidine

CLC Number:

O626.41

TrendMD:

MA Ning, LI Peng-Fei, LI Yong-Hong, LI Zheng-Ming, WANG Ling-Xiu, WANG Su-Hua . Synthesis and Biological Activity of New Phenylsulfonylurea Derivatives[J]. Chem. J. Chinese Universities, 2004, 25(12): 2259.

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Synthesis and Biological Activity of New Phenylsulfonylurea Derivatives

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