Preparation and in Vitro Stability of Targeting Antitumor Drug: Methotrexate-Succinyl-Chitosan Conjugate

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (11): 2103.

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Preparation and in Vitro Stability of Targeting Antitumor Drug: Methotrexate-Succinyl-Chitosan Conjugate

WANG Yin-Song, LI Ying-Xia, SONG Ni, ZHANG Hua

Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, China

Received:2002-10-14 Online:2003-11-24 Published:2003-11-24

Abstract

Abstract: Methotrexate-succinyl-chitosan conjugate was synthesized and its structure was confirmed by UV, IR, ¹HNMR and ¹³CNMR.The flow cytometry analysis shows that N-succinyl-chitosan demonstrated a high affinity for K562 leukemia cells.This conjugate was water-soluble in the range of pH1-14, and the dynamic dialysis study shows that the conjugate was stable.These results provided references for the study of targeting, sustained and controlled release delivery systems of antitumor drugs.

Key words: N-Succinyl-chitosan, Methotrexate, Targeting antitumor drug, Sustained and controlled release

CLC Number:

R931

TrendMD:

WANG Yin-Song, LI Ying-Xia, SONG Ni, ZHANG Hua . Preparation and in Vitro Stability of Targeting Antitumor Drug: Methotrexate-Succinyl-Chitosan Conjugate[J]. Chem. J. Chinese Universities, 2003, 24(11): 2103.

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Preparation and in Vitro Stability of Targeting Antitumor Drug: Methotrexate-Succinyl-Chitosan Conjugate

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