Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (8): 1520.

• Articles • Previous Articles     Next Articles

Synthesis of(2S,3S,4R)-2-n-Pentyl-3,4-diazidyl Tetrahydrothiofene

SHI Hong-Xin1, LIN Hui2, Bloch R.3, Mandville G.3, LIU Hua-Zhang1   

  1. 1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China;
    2. Department of Chemistry, Science Institute, Zhejiang University, Hangzhou 310012, China;
    3. Universitéde Paris-Suid, ICMO, 91405 Orsay Cedex, France
  • Received:2001-05-08 Online:2002-08-24 Published:2002-08-24

Abstract: S, 3S, 4R)-2-n-Pentyl-3, 4 diazidyl tetrahydrothiofene, an important intermediate for the sythesis of (+) deoxybiotin, is enantioselectively synthesized from(+)-4, 10 dioxatricyclo [5.2.1.O2, 6] dec 8 ene 3 ole in eight steps, which provide a novel approach to the enantioselective synthesis of chiral tetrahydrothiofene compounds.

Key words: Deoxybiotin, Chirality, Tetrahydrothiofene, Enantioselectivity

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