Abstract: Two- and four- electron heteropoly blues of samarium-containing polyoxotungstosilicate, poly-oxotungstogermanate, polyoxotungstophosphate and polyoxotungstoarsenate with Keggin structure have been 'synthesized, stoichiometrily determined by elemental analyses and cerimetric titration, and characterized by IR, UV-Vis, ¹⁸³W NMR and ESR spectra.The anti-HIVactivities and toxicities of these compounds have been determined in human Tlymph cells MT-4.It has been found that the four-electron heteropoly blue of samarium-containing polyoxotungstogermanate (HPBR-2) has a high therapeusis index.Medicine tolerance test shows that the cells have no obvious resistance to HPBR-2.The half-inhibition concentrations IC₅₀ of HPBR-2 to acutely infected MT-4 cells have no distinct difference between generation 0 and generation 9.The acute toxicity and Ames test of HPBR-2 have also been carried out.HPBR-2 can not mutate the bacterium typhosum.The half toxicity dose LD50 of HPBR-2 orally administrated to mice is 2988 mg/kg and the maximum tolerance dose is 800 mg/kg, which is 2000 times as high as the dose orally administrated to the human being(20 mg/50 kg).HPBR-2 belongs to one of the complexes with high safety factors.

Key words: Rare earth-containing heteropoly blues, Synthesis, Anti-HIV activity, Toxicity