Species of Rare Earth in Rat Liver

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (1): 1.

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Species of Rare Earth in Rat Liver

LU Ran¹, ZHU Yan-Mei¹, CHEN Hang-Ting², ZHAO Da-Qing¹, NI Jia-Zuan¹, CHEN Dong³, NIE Yu-Xiu³

1. Key Laboratoryof Rare Earth Chemistryand Physics;
2. National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Instituteof App lied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
3. Departmentof Histology and Embryology, School of Basic Medical Science, Jilin University, Changchun 130021, China

Received:2001-02-23 Online:2002-01-24 Published:2002-01-24

Abstract

Abstract: The metabolic accumulation and species of rare earth in rat liver were investigated by ICP-MS and chromatography after the rats were fed by a low dose of mixed rare earth for a long time or the administration of a high dose of lanthanum for a short time. It was found that the content of rare earth in the liver increased with the arising of dose of drug delivery. Their accumulation rate was different, for example, La>Ce>Nd>Pr. The protein which could combine with rare earth specially were not gotten through chromatography. It was suggested that rare earth could bind to many proteins voluntarily, such as some important enzymes and it might be separated from the combined proteins under certain conditions.

Key words: Rare Earth, Liver, Species distribution, ICP-MS

CLC Number:

O614.33

TrendMD:

LU Ran, ZHU Yan-Mei, CHEN Hang-Ting, ZHAO Da-Qing, NI Jia-Zuan, CHEN Dong, NIE Yu-Xiu. Species of Rare Earth in Rat Liver[J]. Chem. J. Chinese Universities, 2002, 23(1): 1.

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Species of Rare Earth in Rat Liver

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