Synthesis and Characterization of an ABA Triblock Copolymer Consisting of Poly(L-Alanine Acid) as A Component and Poly(Ethylene Glycol) as B Component

Abstract

Abstract:

N-Carboxy-L-Aianine acid anhydride (NCA) was synthesized by L-α-alanine and triphosgen. PEG was used to prepare amine-terminated poly(ethylene glycol) (PEG-NH₂), which was used to initiate NCA open ring polymerization and produce PLAA-PEG-PLAA block copolymers of various contents and molecular weights. The structural characteristics of copolymers were shown by IR、¹H NMR、DSC、WAXD、CD etc. The results showed that products of NCA open ring polymerization initiated by PEG-NH₂ were block copolymers. Copolymer's contents and number-average molecular weights were obtained by ¹H NMR. The hydrophilicity of PLAA were improved by adding PEG. The results of CD showed the copolymers in aqueous solution existed as α-helical conformation.

Key words: Poly(L-α-Alanine acid), Open ring polymerization, Block copolymer

CLC Number:

O632

TrendMD:

ZHANG Guo-Lin, MA Jian-Biao. Synthesis and Characterization of an ABA Triblock Copolymer Consisting of Poly(L-Alanine Acid) as A Component and Poly(Ethylene Glycol) as B Component[J]. Chem. J. Chinese Universities, 2001, 22(S1): 227.

[1]	FAN Juanjuan, HAN Yuanyuan, CUI Jie. Monte Carlo Simulation of the Transformation Control of ABC Triblock Copolymer Micelles from Multicompartment Structure to Multicore Structure [J]. Chem. J. Chinese Universities, 2021, 42(3): 857.
[2]	SHI Xiaoyu, WANG Songmeng, LIU Lingyan, CHANG Weixing, LI Jing. Controllable Synthesis of Amphiphilic Block Copolymer PMnEOS-b-PAA and co-Assembly Morphologies of PMDEOS-b-PAA/PS-b-PAA [J]. Chem. J. Chinese Universities, 2020, 41(11): 2545.
[3]	WANG Lin, ZHANG Yanhui, Arzugul Muslim, LAN Haidie. Morphology and Size Regulation of Polyaniline Induced by PS-b-P2VP as Template and Its Electrochemical Characters [J]. Chem. J. Chinese Universities, 2019, 40(8): 1748.
[4]	FENG Wenya, QIAO Juan, QI Li, LI Zhiwei. Sepatation of Antipyretic Analgesics by CapillaryElectrochromatography with Block Copolymer Coating^† [J]. Chem. J. Chinese Universities, 2018, 39(8): 1640.
[5]	ZHAO Junqiang, YAN Caixia, CHEN Ze, YANG Ning, FENG Xia, ZHAO Yiping, CHEN Li. Synthesis and Self-assembly Properties of Intracellular Redox Bioresponsive Block Copolymers with Hepatoma-targeting Groups^† [J]. Chem. J. Chinese Universities, 2018, 39(7): 1592.
[6]	RONG Jingjing,MA Lan,ZHU Youliang,HUANG Yineng,SUN Zhaoyan. Simulation of Perforated Lamelar Structures of Diblock Copolymer Induced by Surface Patterns^† [J]. Chem. J. Chinese Universities, 2018, 39(12): 2805.
[7]	ZHANG Yixin, WANG Mengxue, ZHANG Zheyuan, MI Puke, WANG Tinglan. Polyethylene-b-poly(ethylene/1-octene) Block Copolymer Prepared via Novel Dinuclear FI/Nickel(Ⅱ) α-Diiminecatalytic Systems [J]. Chem. J. Chinese Universities, 2017, 38(8): 1497.
[8]	LU Zhiwei, CHEN Shun, JU Yanyun, ZHANG Yang, XIONG Chuanxi, DONG Lijie. Synthesis and Properties of PS-b-P(DMS-stat-VMS) Block Copolymer [J]. Chem. J. Chinese Universities, 2017, 38(8): 1484.
[9]	DONG Xiaoming, YUAN Baoming, CHEN Bingpeng, HE Chaoliang, WANG Jincheng, CHEN Xuesi. In vitro Antibacterial Activity of PLGA-PEG-PLGA Thermosensitive Hydrogels Loaded with Vancomycin [J]. Chem. J. Chinese Universities, 2017, 38(5): 866.
[10]	WANG Xiaoqing, LING Jun, SHEN Zhiquan. Synthesis and Self-assembly of Thermoplastic Elastomer Poly(ε-decalactone)-Poly(L-lactide)-PEG with Rare Earth Catalyst^† [J]. Chem. J. Chinese Universities, 2016, 37(6): 1182.
[11]	WANG Yingying, CUI Jie, HAN Yuanyuan, JIANG Wei, SUN Yingchun. Monte Carlo Simulation on Self-assembly of AB Diblock Copolymers/Nanoparticles Complex Confined in Parallel Walls^† [J]. Chem. J. Chinese Universities, 2016, 37(5): 1010.
[12]	ZHANG Lixin, WANG Jintao, YANG Yongfang, ZHAO Hanying. Novel Method of Preparation of Diblock Copolymers with Disulfide Bonds at Junction Points^† [J]. Chem. J. Chinese Universities, 2016, 37(1): 161.
[13]	ZHANG Lili, CHEN Qiaoyue, ZHOU Hengwei, SHI Tongfei, HUANG Yineng. Influences of Topological Chain Structures to the Crystallization of Block Copolymers^† [J]. Chem. J. Chinese Universities, 2015, 36(9): 1832.
[14]	LIU Dongmei, DAI Lijun, DUAN Xiaozheng, SHI Tongfei, ZHANG Hanzhuang. Monte Carlo Simulation of Interfacial Properties in Homopolymer/Diblock Copolymer/Homopolymer Ternary Polymer Blends^† [J]. Chem. J. Chinese Universities, 2015, 36(9): 1752.
[15]	MA Lili, SHAO Jun, YANG Chenguang, TANG Zhaohui, CHEN Xuesi. Synthesis and Property of PDLA-PBS-PDLA Tri-block Copolymer^† [J]. Chem. J. Chinese Universities, 2015, 36(11): 2329.

Synthesis and Characterization of an ABA Triblock Copolymer Consisting of Poly(L-Alanine Acid) as A Component and Poly(Ethylene Glycol) as B Component

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments