Abstract:

A tripodal ligand,Tris{2-[N-(4'-hydroxy-3'-methoxy-phenyl)-methyJyimino-ethyl]-amine (L), and its complexes with lanthanide nitrates have been synthesized. These new complexes with the general formula of Ln(NO₃)₃L·4H₂0 (where Ln=La, Pr, Eu, Gd, Tb, Er) were characterized by elemental analysis, IR spectra, thermal analysis and ¹H NMR spectra. All the complexes are stable in air. The IR and ¹H NMR spectra of the ligand and its complexes show that all the C=N groups take part in coordination to the rare earth ions. The thermal behaviors of the La and Eu complexes are similar. The losses occur at 70~75℃ and 176~185℃ corresponding to the loss of two H₂O and two H₂O, respectively. The weight losses found in this process compare with the theoretical values, so the complexes have lattice water and coordination water. The antitumor activities of partial complexes have been investigated.

Key words: Tripodal ligand, Lanthanide nitrate, Complexes, Synthesis, Antitumor activity