Studies on the Kinetics of Cobalt(Ⅲ) Complexes with Various Charge and Chirality Crossing Human Erythrocyte Membrane

Abstract

Abstract: The kinetics that four complexes with various charge and chirality crossed human erythrocyte membrane was studied, and their rate constants(k) of first-order kinetics were determined. The experimental results showed that the [Co(C₂O₄)₃]^3- has an obviously higher rate of cross-membrane[Co(en)3]³⁺than, [Co(en)₂(C₂O₄)]⁺ and [Co(en)(C₂O₄)₂]^-,[Co(en)₂(C₂O₄)]⁺and[Co(en)(C₂O₄)₂]^- the k values of the latter three kinds of complexes increased gradually with the decreasing of their positive charge, their mechanism of transmembrane transport are simple passive diffusion. The rate of transmembrane transport of [Co(C₂O₄)₃]^3- was obviously inhibited by DIDS, an anion channel inhibitor, the inhibition rate is 51.95%, its mechanism of transmembrane transport has been considered involving anion channel transport and passive diffusion. The uptake rate of L-[Co(C₂O₄)₃]^3- is larger than that of D-[Co(C₂O₄)₃]^3- by human erythrocytes, this exhibited that there was chiral selectivity when erythrocytes took up the optical isomers.

Key words: Cobalt, Human erythrocytes, Kinetics

CLC Number:

O641.4

TrendMD:

WU Gang, LI Rong-Chang, QIAO Xiu-Wen, WANG Jian-Cheng . Studies on the Kinetics of Cobalt(Ⅲ) Complexes with Various Charge and Chirality Crossing Human Erythrocyte Membrane[J]. Chem. J. Chinese Universities, 2001, 22(7): 1077.

[1]	WEI Chunhong, JIANG Qian, WANG Panpan, JIANG Chengfa, LIU Yuefeng. Atomic Scale Investigation of Pt Atoms/clusters Promoted Co-catalyzed Fischer-Tropsch Synthesis [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220074.
[2]	SUN Cuihong, LYU Liqiang, LIU Ying, WANG Yan, YANG Jing, ZHANG Shaowen. Mechanism and Kinetics on the Reaction of Isopropyl Nitrate with Cl， OH and NO₃ Radicals [J]. Chem. J. Chinese Universities, 2022, 43(2): 20210591.
[3]	YU Bin, CHEN Xiaoyan, ZHAO Yue, CHEN Weichang, XIAO Xinyan, LIU Haiyang. Graphene Oxide-based Cobalt Porphyrin Composites for Electrocatalytic Hydrogen Evolution Reaction [J]. Chem. J. Chinese Universities, 2022, 43(2): 20210549.
[4]	HE Yujing, LI Jiale, WANG Dongyang, WANG Fuling, XIAO Zuoxu, CHEN Yanli. Zinc-based Activated Fe/Co/N Doped Biomass Carbon Electrocatalysts with High Oxygen Reduction Activity [J]. Chem. J. Chinese Universities, 2022, 43(11): 20220475.
[5]	HOU Congcong, WANG Huiying, LI Tingting, ZHANG Zhiming, CHANG Chunrui, AN Libao. Preparation and Electrochemical Properties of N-CNTs/NiCo-LDH Composite [J]. Chem. J. Chinese Universities, 2022, 43(10): 20220351.
[6]	CHENG Xiao, K BORA Debajeet, GLANS Per⁃Anders, GUO Jinghua, LUO Yi. An In-depth Theoretical Study of Ligand Field and Charge Transfer Effects on Co²⁺_2pL_2，3-edges X-ray Absorption Spectra [J]. Chem. J. Chinese Universities, 2021, 42(7): 2197.
[7]	MA Zihui, WANG Mengyan, CAO Hongyu, TANG Qian, WANG Lihao, ZHENG Xuefang. Transient Absorption and Decay Kinetic Properties of Photo-excited Metal Coordinated Tetraphenylporphyrin [J]. Chem. J. Chinese Universities, 2021, 42(3): 767.
[8]	SHUAI Die, ZHAO Meijuan, CHEN Bingnian, WANG Li. Inhibitory Effect of Four Kinds of Keegin-type Phosphomolybdate on Tyrosinase and Melanin Formation and Its Antioxidant Activities [J]. Chem. J. Chinese Universities, 2021, 42(12): 3579.
[9]	WU Shuaini, ZHU Pengfei, SHI Huaiqi, LI Na, HU Zhaoxia, CHEN Shouwen. Preparation of CoCr_x/SAPO-34 Catalyst and Its Catalytic Combustion Performance for 1，2-Dichloroethane [J]. Chem. J. Chinese Universities, 2021, 42(12): 3731.
[10]	ZHANG Aiqin, WANG Man, SHEN Gangyi, JIN Jun. Interactions Between Polybrominated Diphenyl Ethers and Human Serum Albumin Using SPR and Molecular Docking [J]. Chem. J. Chinese Universities, 2020, 41(9): 2054.
[11]	CAO Meng, LIU Yang, ZHANG Shangxi, WANG Zhenxi, XU Sheng. Synthesis and Photocatalytic Hydrogen Evolution Properties of Chitosan Cobalt Complex ^† [J]. Chem. J. Chinese Universities, 2020, 41(4): 735.
[12]	WANG Lianping,LI Qingjie,LIU Xiaoyan,REN Yueying,YANG Xiuwei. Screening of Cholinesterase Inhibitors in Fructus Evodiae Alkaloids Based on UFLC-MS/molecular Simulation ^† [J]. Chem. J. Chinese Universities, 2020, 41(1): 111.
[13]	FANG Liang,DING Xiaoli,SONG Yun,LIU Dongming,LI Yongtao,ZHANG Qingan. Effect of Morphological Tuning on Electrochemical Performance of Perovskite LaCoO₃ Anodes^† [J]. Chem. J. Chinese Universities, 2019, 40(7): 1456.
[14]	SUN Guangdong, PAN Xiaopeng, ZHONG Yuhao, CHEN Enyu, HUANG Yi, SHAO Jianzhong. Photopolymerization Kinetics of Poly(Acrylate Acid) Hydrogels Induced by Blue Light ^† [J]. Chem. J. Chinese Universities, 2019, 40(11): 2404.
[15]	XIAO Biyuan,QIU Jiangyuan,QIN Fanghong,WAN Ting,XU Yaqun,NONG Xiaohui,HUANG Zaiyin. Study on Particle Size Effect on Adsorption Thermodynamics and Kinetics of Cubic Nano-Cu₂O ^† [J]. Chem. J. Chinese Universities, 2019, 40(10): 2214.

Studies on the Kinetics of Cobalt(Ⅲ) Complexes with Various Charge and Chirality Crossing Human Erythrocyte Membrane

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments