A Study of Asymmetric Baeyer-Villiger Reaction of 2-Phenylcyclohexanone Catalyzed by Chiral Salen-Cu(Ⅱ) and Oxazoline-Cu(Ⅱ) Complexes

Chem. J. Chinese Universities ›› 2001, Vol. 22 ›› Issue (2): 223.

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A Study of Asymmetric Baeyer-Villiger Reaction of 2-Phenylcyclohexanone Catalyzed by Chiral Salen-Cu(Ⅱ) and Oxazoline-Cu(Ⅱ) Complexes

PENG Yun-Gui², FENG Xiao-Ming^1,2, WANG Bin², LI Zhi², YANG Gui-Shu², JIANG Yao-Zhong²

1. Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai 200032, China;
2. Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, Beijing 100050, China

Received:1999-08-31 Online:2001-02-24 Published:2001-02-24

Abstract

Abstract: In this paper, we have studied the asymmetric Baeyer-Villiger reaction of 2-phenylcyclohexanone catalyzed by Cu(Ⅱ) complexes which derived from a series of chiral Salen and oxazoline ligands, as well as designed and synthesized the new chiral ligands Ⅲ, Ⅳ, Ⅴ. And the configuration of complex Ⅴ-Cu(Ⅱ) was determined by X-ray analysis. We also investigated the influence of co-oxidant, solvent, etc. on the reactivity and selectivity.

Key words: Asymmetric catalysis, Baeyer-Villiger reaction, Chiral ligand

CLC Number:

O621
O251

TrendMD:

PENG Yun-Gui, FENG Xiao-Ming, WANG Bin, LI Zhi, YANG Gui-Shu, JIANG Yao-Zhong. A Study of Asymmetric Baeyer-Villiger Reaction of 2-Phenylcyclohexanone Catalyzed by Chiral Salen-Cu(Ⅱ) and Oxazoline-Cu(Ⅱ) Complexes[J]. Chem. J. Chinese Universities, 2001, 22(2): 223.

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A Study of Asymmetric Baeyer-Villiger Reaction of 2-Phenylcyclohexanone Catalyzed by Chiral Salen-Cu(Ⅱ) and Oxazoline-Cu(Ⅱ) Complexes

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