Studies on Synthesis and Anticancer Activity of Thiosemicarbazones

Abstract

Abstract: Sixteen of thiosemicarbazone(Ⅰ) was synthesized. Hydrazine reacts with carbondisulfide and dimethyl sulfate in the presence of potassium hydroxide to form compound Ⅱ with yield 60. compound Ⅱ reacts with ketone or aldehyde to form compound Ⅲ. Compound Ⅲ reacts with Nsubstituted piperazine to form Ⅰ with yield 27-85. The structures of the compounds were comfirmed by IR, NMR, elemental analysis, and the results shows that the thiosemicarbazone with proper substituents has somewhat activity. These compounds are valuable ones for being studied further.

Key words: Thiosemicarbazone, Anticancer activity, Organic synthesis, Methyl hydrazinecarbodithioate

CLC Number:

R914

TrendMD:

HU WeiXiao, SUN Nan, YANG ZhongYu . Studies on Synthesis and Anticancer Activity of Thiosemicarbazones[J]. Chem. J. Chinese Universities, 2001, 22(12): 2014.

[1]	ZHAO Ying, QIAO Ling, ZHAO Guofeng, CHEN Li. Synthesis and Biological Activity of Lycorine Derivatives Containing Malate Ester [J]. Chem. J. Chinese Universities, 2021, 42(9): 2789.
[2]	LIU Dan, HU Xiufang, ZHENG Yanyan, PAN He, LUO Shuwei, HONG Fang, ZHAO Wenna, JIANG Meihong, ZHU Yunhui, SHAO Jingwei, WANG Wenfeng. Synthesis of Lipiophilic Cations of Anthraquinone and Their Anticancer Activities^† [J]. Chem. J. Chinese Universities, 2015, 36(6): 1100.
[3]	KUANG Daizhi, FENG Yonglan, YU Jiangxi, ZHANG Fuxing, JIANG Wujiu, PENG Yan, ZHU Xiaoming, TAN Yuxing. Microwave Assisted Solid-state Synthesis, Crystal Structure, Properties of the Coordination Polymer Constructed from Tricyclohexyltin Hydroxide and o-Ferrocenylcarbonyl Benzoic Acid^† [J]. Chem. J. Chinese Universities, 2014, 35(8): 1629.
[4]	LI Xiaoliu, MA Donglai, YANG Hailong, TAN Guanhai, DU Huiru, WANG Kerang, ZHANG Pingzhu, CHEN Hua. Synthesis, Antitumor Activity and DNA Binding of cridine-polyamine Conjugates^† [J]. Chem. J. Chinese Universities, 2014, 35(6): 1181.
[5]	LIU Haibin, LÜ Ping, PAN Ningning, AI Limei, LIU Yongxiang. Synthesis and In vitro Anticancer Activity of Novel Quinazoline Derivatives Containing Thiosemicarbazone Structure^† [J]. Chem. J. Chinese Universities, 2014, 35(5): 981.
[6]	HAO Hequn, YAO Ping. In Vitro Anticancer Effects of Doxorubicin Loaded BSA-dextran Nanoparticles with Different Molecular Weights of Dextran and Different Dextran Conjugation Degrees^† [J]. Chem. J. Chinese Universities, 2014, 35(3): 652.
[7]	LIU Cheng, ZHENG Yan-Yan, HONG Fang, HU Jian-Da, ZHAO Wen-Na, YUAN Yao-Feng, SHAO Jing-Wei, WANG Wen-Feng. Synthesis and Anticancer Activity Evaluation of Derivatives of Emodin [J]. Chem. J. Chinese Universities, 2013, 34(6): 1408.
[8]	WEI Tai-Bao, LI Jun-Jian, LIN Qi, YAO Hong, GUO Ying, BAI Cui-Bing, XIE Yong-Qiang, ZHANG You-Ming. Highly Selective Colorimetric Recognition of Copper Ions Based on N-Aryl Coumarin Methyl Ketone Thiosemicarbazone Receptors [J]. Chem. J. Chinese Universities, 2012, 33(11): 2452.
[9]	HUANG Yi-Bing, ZHAI Nai-Cui, GAO Gui, CHEN Yu-Xin. Effects of Net Charge on Biological Activities of Alpha-helical Anticancer Peptides [J]. Chem. J. Chinese Universities, 2012, 33(06): 1252.
[10]	HUANG Xiao-Chun, ZHENG Jun-Sheng, CHEN Tian-Feng, ZHANG Yi-Bo, LUO Yi, ZHENG Wen-Jie. Synthesis, Antioxidant and Anticancer Activities of 1,2,5-Selenadiazole Pyrimidine Heterocyclic Derivative ASPO [J]. Chem. J. Chinese Universities, 2012, 33(05): 976.
[11]	LI Xiao-Liu*, ZHANG Hong-Bo, ZHU Zheng-Gang, CHEN Hua, DUAN Ke-Fang, .... Efficient and Stereoselective Synthesis of Azasugar Derivatives Based on Microwave Assisted 1,3-Dipolar Cycloaddition [J]. Chem. J. Chinese Universities, 2010, 31(9): 1791.
[12]	LIU Ya-Nan, YANG Fang, MEI Wen-Jie, LIU Jie, ZHENG Wen-Jie. Synthesis and in vitro Anticancer Activities of Chiral Ruthenium Complexes and Interaction of the Complex with Bovine Serum Albumin [J]. Chem. J. Chinese Universities, 2010, 31(3): 435.
[13]	WANG Wen-Long, HUANG Yan-Lan, HU Wei-Xiao, SHAN Shang. Synthesis,Structures and Anti-tumor Properties of Capsaicin Analogues [J]. Chem. J. Chinese Universities, 2010, 31(12): 2400.
[14]	JIANG Cheng, CHEN Su-Ting, YOU Qi-Dong*, LI Zhi-Yu, TANG Wei-Juan. Synthesis and Bioactivities of Novel Indolocarbazole Derivatives [J]. Chem. J. Chinese Universities, 2009, 30(10): 1972.
[15]	XIAO Yong-Jun, WANG Jian-Guo, LIU Xing-Hai, LI Yong-Hong, LI Zheng-Ming*. Molecular Design, Synthesis and Biological Activity Evaluation of Novel AHAS Inhibitors Basedon Receptor Structure [J]. Chem. J. Chinese Universities, 2007, 28(7): 1280.

Studies on Synthesis and Anticancer Activity of Thiosemicarbazones

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments