Template Effect of Adenine-contained Polymer Nucleic Acid Analog on the Coupled Action of Uridine by N-(O,O’-Diisopropyl)phosphoryl Alanine

Chem. J. Chinese Universities ›› 2001, Vol. 22 ›› Issue (10): 1672.

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Template Effect of Adenine-contained Polymer Nucleic Acid Analog on the Coupled Action of Uridine by N-(O,O’-Diisopropyl)phosphoryl Alanine

XIANG Hong-Qi¹, HU Jian-Jun¹, JIANG Yang¹, YANG Cheng-Dui², ZHAO Yu-Fen¹

1. Key Laboratoryf or Bioorganic Phosphorus Chemistryof Educational Ministry;
2. Analysis Center, Depa rtment of Chemistry, Schoolof Life Sciencesand Engineering, Tsinghua University, Beijing 100084, China;
3. Instituteof Chemistry, Chinese Academy of Sciences, Beijing 100080, China

Received:2000-08-29 Online:2001-10-24 Published:2001-10-24

Abstract

Abstract: The effect of poly[ β-(N⁷ adeninyl)ethyl methacrylate] on the reaction of uridine with N-( O,O'-diisopropyl)phosphoryl alanine was studied. It was found that the adenine-contained polymer nucleic acid analog acted as a template to accelerate the coupled action of uridine by phosphoryl alanine. In the presence of the nucleic acid analog, the yield of uridyl nucleotides and uridyl oligonucleotides were increased significantly. The template effect of poly[β-(N⁷-adeninyl)ethyl methacrylate] showed a selectivity to the coupled action of uridine but not the adenosine. In addition, since the skeleton polymethacrylate did not show any catalytic effect, the template effect of poly[ β-(N⁷-adeninyl)ethyl methacrylate] must the due to the adenine-bonded side chain.

Key words: Phosphoryl amino acid, Nucleoside, Polymer nucleic acid analog, Template effect

CLC Number:

O629
O632

TrendMD:

XIANG Hong-Qi, HU Jian-Jun, JIANG Yang, YANG Cheng-Dui, ZHAO Yu-Fen . Template Effect of Adenine-contained Polymer Nucleic Acid Analog on the Coupled Action of Uridine by N-(O,O’-Diisopropyl)phosphoryl Alanine[J]. Chem. J. Chinese Universities, 2001, 22(10): 1672.

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Template Effect of Adenine-contained Polymer Nucleic Acid Analog on the Coupled Action of Uridine by N-(O,O’-Diisopropyl)phosphoryl Alanine

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