New Fingerprinting Method Based on the Distribution of Nucleoside Compounds for Marine Animal Drugs by HILIC-ESI-TOF/MS

doi:10.3969/j.issn.0251-0790.2012.01.007

Abstract

Abstract: The feasibility of identification of the authenticity for various marine animal drugs was investigated by a fingerprinting method based on the distribution of nucleoside compounds, and a new method for the discrimination of precious animal drugs was provided. Sixteen nucleoside compounds in various marine animal drugs were determined by hydrophilic interaction liguid chromatography-electrospray ionization-time of flight-mass spectrometry(HILIC-ESI-TOF/MS). Characteristic fingerprint based on the distribution of 16 nucleosides was constructed, and it was used for identification of the authenticity of various marine animal drugs combined with similarity analysis and clustering analysis. The results indicated that the proposed characteristic fingerprint could reflect the inherent characteristics of their own for various marine animal drugs. Furthermore, it could be used to distinguish different marine animal drugs combined with similarity analysis and clustering analysis. In conclusion, the developed fingerprinting method is expected to be a powerful tool for the identification of animal drugs.

Key words: Nucleoside, Animal drug, Fingerprint, Hydrophilic interaction liquid chromatography(HILIC), Time of flight-mass spectrometry(TOF/MS)

CLC Number:

O652.1

TrendMD:

ZHAO Heng-Qiang, CHEN Jun-Hui, SHI Qian, LI Xin, CAO Wei, LI Jing-Xi, WANG Xiao-Ru. New Fingerprinting Method Based on the Distribution of Nucleoside Compounds for Marine Animal Drugs by HILIC-ESI-TOF/MS[J]. Chem. J. Chinese Universities, 2012, 33(01): 44.

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