Abstract:

Hypoxic cells are present in most solid tumors of the men and animals, which occur in the interface between the well-oxygenated tissue and the necrotic regions. Hypoxia can be a direct cause of therapeutic resistance because some drugs and radiation require oxygen to be maximally cytotoxic. Cellular metabolism is altered under hypoxic conditions. In addition there is evidence that Hypoxia can enhance genetic instability in tumor cells thus allowing more rapid development of drug resistance cells.