Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (S1): 146.

• Chemistry in Life Sciences • Previous Articles     Next Articles

Comparison of the Metabolism of Eprinomectin in Lactating Dairy Cattle, Beef Cattle and Rats

ZENG Zhao-Pie, ANDREW Nick, NARASIMHAN Nachu,VENKATARAMAN Kalpana, HALLEY Bruce   

  1. Department of Pharmacokinetics and Drug Metabolism, Merial, 2100 Ronson Road, Iselin, NJ 08830
  • Online:2000-12-31 Published:2000-12-31

Abstract:

Eprinomectin is a parasiticide used in beef and dairy cattle. It was not extensively metabolized in either cattle or Spranue-Dawley VAF rats, All the metabolites detected in cattle tissues and milk were also detected in rat tissues and feces. Metabolism of eprinomectin in cattle and rats were qualitalively similar. Therefore the Sprangue-Dawley VAF rat is a good laboratory animal model to evaluate the human food toxicology safety of eprinomectin.

TrendMD: