Synthesis of Some Polyhydroxysterols and Investigation of Relationship Between Their Structure and Cytotoxicity

Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (9): 1399.

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Synthesis of Some Polyhydroxysterols and Investigation of Relationship Between Their Structure and Cytotoxicity

CUI Jian-Guo^1,3, ZENG Long-Mei¹, SU Jing-Yu¹, PENG Wen-Lie², XU An-Long²

1. Schoolof Chemistryand Chemical Engineering, Zhongshan University, Guangzhou 510275, China;
2. Schoolof Life Science, Zhongshan University, Guangz hou 510275, China;
3. Depa rtment of Chemistry, Guangx i Teachers College, Nanning 530001, China

Received:1999-08-21 Online:2000-09-24 Published:2000-09-24

Abstract

Abstract: In this paper, we have prepared six analogues of 24-methylenecholest-4-en-3β,6β-diol(1) and investigated the relationships between the biological activity and their structures. The results showed that the double bond in the molecule played an impor tant role to the cytotoxicity of these polyhydroxysterols. Their cytotoxicity reduced obviously while the double bond in steroidal nucleus or side-chain was saturated. Compounds 5 and 8 showed a moderate cytotoxic activity against human gastric carcinoma cells(MGC) and cervical carcinoma cells(HELA).

Key words: Polyhydroxysterols, Synthesis of sterols, Cytotoxicity, Structure activity relationship

CLC Number:

O629.21

TrendMD:

CUI Jian-Guo, ZENG Long-Mei, SU Jing-Yu, PENG Wen-Lie, XU An-Long. Synthesis of Some Polyhydroxysterols and Investigation of Relationship Between Their Structure and Cytotoxicity[J]. Chem. J. Chinese Universities, 2000, 21(9): 1399.

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Synthesis of Some Polyhydroxysterols and Investigation of Relationship Between Their Structure and Cytotoxicity

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