Structure-activity Relationships for Antiplasmodial Activity Among Aminoquinolines

Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (2): 219.

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Structure-activity Relationships for Antiplasmodial Activity Among Aminoquinolines

QI Yu-Hua¹, XU Lu¹, LIU Zhong-Ying²

1. Changchun Institute of Applied Chemistry, Academia Sinica, Changchun 130022, China;
2. Norman Bethune University of Medical Sciences, Changchun 130023, China

Received:1999-07-02 Online:2000-02-24 Published:2000-02-24

Abstract

Abstract: The extended gravitational index G_Q and quantum-chemical descriptors were calculated for the relationship analysis of aminoquinolines. An evolutionary algorithm was described for variable selection and building QSARmodels. And the quasi-newton neural networks were employed with better results.

Key words: Extended gravitational index, Quantum-chemical descriptors, Aminoquinolines, Evolutionary algorithm, QSAR

CLC Number:

O639

TrendMD:

QI Yu-Hua, XU Lu, LIU Zhong-Ying. Structure-activity Relationships for Antiplasmodial Activity Among Aminoquinolines[J]. Chem. J. Chinese Universities, 2000, 21(2): 219.

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Structure-activity Relationships for Antiplasmodial Activity Among Aminoquinolines

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