Application of Genetic Programming Coupling with Genetic Algorithm

Abstract

Abstract: GA-GPis an algorithm for dealing with all kinds of nonlinear function relationships and fraction relationships, which use GP(Genetic programming) to create new individuals and GA(Genetic algorithm)to optimize them at the same time. In this way we make full advantage of GAand GP. We discuss the application of this algorithm in quantitative structure-activity relationships(QSAR) in the medicinal field. The result shows that GA-GPis better than ANNand mathematical expressions could be obtained. Expressions clearly express and explain QSARof the medicine. All can show GA-GPhas very wide applications in the medicinal field of the molecule design.

Key words: Genetic algorithm, Genetic programming, QSAR

CLC Number:

O639

TrendMD:

ZHOU Xiang-Dong, LI Tong-Hua, BIAN Fang, QIAN Jun-Lü. Application of Genetic Programming Coupling with Genetic Algorithm[J]. Chem. J. Chinese Universities, 2000, 21(2): 216.

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Application of Genetic Programming Coupling with Genetic Algorithm

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