Synthesis of 3-Alkyl/Aryl-6-(1’-N-β-D or α-L-Acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles

Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (8): 1233.

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Synthesis of 3-Alkyl/Aryl-6-(1’-N-β-D or α-L-Acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles

YU Jian-Xin¹, LIU Fang-Ming¹, LU Wen-Jie¹, LI Yan-Ping¹, TIAN Li-Li¹, LIU Yu-Ting¹, LIU Cong², CAI Meng-Shen³

1. Department of Chemistry, Xinjiang University, Ulumuqi 830046, China;
2. Department of Chemistry, Xinjiang Normal University, Ulumuqi 830011, China;
3. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, China

Received:1998-12-28 Online:1999-08-24 Published:1999-08-24

Abstract

Abstract: 3-Alkyl/aryl-4-amino-5-mercapto-1,2,4-triazoles(5) were condensed with 2,3,4,6-tetra-Oacetyl-β-D-glucopyranosyl isothiocyanate(3) or 2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl isothiocyanate(4) in anhydrous EtO Hunder reflux to afford 14 novel 3-alkyl/aryl-6-(1'-N-2',3',4',6'-tetra Oacetyl-β-D-glucopyranosyl or 1'-N-2',3',4'-tri-O-acetyl-α-L-rhamnopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles(6a_6i, 7a_7e). Their structures were confirmed by elemental analysis, IRand ₁HNMR spectral data.

Key words: s-Triazolo[3,4-b] 1,3,4-thiadiazole, N-Glycoside, Synthesis

CLC Number:

O626

TrendMD:

YU Jian-Xin, LIU Fang-Ming, LU Wen-Jie, LI Yan-Ping, TIAN Li-Li, LIU Yu-Ting, LIU Cong, CAI Meng-Shen . Synthesis of 3-Alkyl/Aryl-6-(1’-N-β-D or α-L-Acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles[J]. Chem. J. Chinese Universities, 1999, 20(8): 1233.

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Synthesis of 3-Alkyl/Aryl-6-(1’-N-β-D or α-L-Acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles

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