Abstract: Polymeric drug containing active agent in the backbone was one of the controlled release systems. In this paper, some polymers, which have an antineoplastic agent(hexestrol) in the backbone, have been synthesized by copolymerization hexestrol bis(hydrogen succinate) with sebacic acid(SA). Hexestrol bis(hydrogen succinate) was prepared by reaction hexestrol with succinic anhydride. The degradation properties in vitro under various pHconditions were also investigated. The results showed that the degradation rates increase with the increase of pH, and at the same time, the degradation rates increase with the increase in sebacic acid content in the copolymers.

Key words: Polymer-controlled drug release systems, Polyesteranhydrides, Melt-polycondensation, Hexestrol