Abstract: Piezoelectric immunosensor has a vast future of applications in biochemistry and clinical medicine. Mass amplification immune assay could improve the detection sensitivity remarkably and would enlarged the application fields remarkably. In this paper, we first developed amplification immune assay of piezoelectric immunosensor using biotinavidin system. The mass adsorbed on the crystal surface was amplified and the detection sensitivity of the sensor improved remarkably so that the detection range was enlarged and the detection low limit of linear range was declined.

Key words: Piezoelectric immunosensor, Biotin-avidin system, Mass amplification immune assay G)