Embedment and Deliverance of 5-Fluorouracil from Blended Membrane of Silk Fibroin and 5-Fluorouracil

Abstract

Abstract: The silk fibroin membrane is an amphoteric ion-exchange membrane composed of both weak acidic and weak basic groups. 5-FluorouraciLIs an anti-cancer drug. The condition of 5-fluorouracil blended into silk fibroin membrane has been investigated, then deliverance of 5-fluorouracil from blended membrane of silk fibroin and 5-fluorouracil was measured in the pH range from 3 to 9. The results of SEM, FTIR, DSC show that 5-fluorouracil could be evenly blended into silk fibroin protein. After coating with silk fibroin, the dissolve rate of 5-fluorouracil fixed on silk fibroin and 5-fluorouracil blended membrane could be descended, and the delivery time of 5-fluorouracil could be prolonged. The delivery time and dissolve rate also depends on pHvalues of soaking solution. It is expected that silk fibroin membrane could be used as the matrix of 5-fluorouracil delivery system.

Key words: Silk fibroin membrane, 5-Fluorouracil, Drug matrix, Deliverance

CLC Number:

O629.73

TrendMD:

CHEN Jian-Yong, LIU Guan-Feng, SHEN Zhi-Quan . Embedment and Deliverance of 5-Fluorouracil from Blended Membrane of Silk Fibroin and 5-Fluorouracil[J]. Chem. J. Chinese Universities, 1999, 20(10): 1646.

[1]	LI Xianhua, ZHANG Leigang, WANG Xuexue, YU Qingbo. Fabrication and Multi-antitumor Effect of Novel Dextran-hemin Crosslinked Micelles Triggered by Photo Conditions^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 1004.
[2]	TONG Chunyi, TANG Fengxia, LIU Bin, LIAO Hongdong, LIU Xuanming. Preparation of Micro-spheres Co-carried Anti-tumor Drug and Sensitizer(5-Fu-COS/SeNP) and Their Inhibiting Tumorous Cellular Growths Activity^† [J]. Chem. J. Chinese Universities, 2014, 35(7): 1603.
[3]	YIN Jing-Bo, CHEN Hong-Dan, LUO Kun, ZHUANG Xiu-Li, CHEN Xue-Si, CAO Tian. Preparation and Properties of Biodegradable Microspheres Containing 5-Fluorouracil [J]. Chem. J. Chinese Universities, 2005, 26(6): 1174.
[4]	ZHANG Qiu-Lin, ZENG Ji-Chao., XU Xin-Hua, ZHOU Bing, LU Rui-Liang, CHEN Xiong, LI Yan-Jie . Synthesis and Biologic Activities of Glycerothiophospholipid Conjugate of Tegafur Containing Aryl-selenium Group in the Glycerol Skeleton [J]. Chem. J. Chinese Universities, 2005, 26(11): 2046.
[5]	LI Juan, LI Jing, QI Yan-Fei, WANG Hong-Fang, WANG En-Bo, HU Chang-Wen, XU Lin, WU Xin-Yu. Synthesis and Anti-liver Cancer Activity of 5-Fluorouracil Salt of 12-Tungstoboric Acid [J]. Chem. J. Chinese Universities, 2004, 25(6): 1010.
[6]	MAO Man-Jun, TIAN Xuan, CHEN Yao-Zu. Syntheses and Antitumor Activities of Spin-labeled₅-Fluorouracil Derivatives [J]. Chem. J. Chinese Universities, 1998, 19(3): 395.
[7]	FAN Chang-Lie, HU Bin, ZHUO Ren-Xi, DU Yang . Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs [J]. Chem. J. Chinese Universities, 1997, 18(1): 149.
[8]	LUO Xuan-Gan, ZHUO Ren-Xi, LI Man-Qing . Studies of the Synthesis and Antitumor Activity of 5-Fluorouracil Derivatives Containing D-Aminoglucose Residue [J]. Chem. J. Chinese Universities, 1996, 17(9): 1416.
[9]	LUO Yi, ZHUO Ren-xi, FAN Chang-Lie. Synthesis of Crosslinked Polyphosphates and Drug Release [J]. Chem. J. Chinese Universities, 1995, 16(10): 1633.
[10]	SUN Chan-Jun, WANG Yi-Gui, CHEN Zai-Cheng, XUE Peng, HU Wei-Feng, XU Bei-Li, ZHAO Yao-Ran, WANG Mei-Ling. Studies on the Synthesis of Glycosides(Ⅳ)─Synthesis of N-Glucuronides of 5-Fluorouracil and Their Antitumor Activities [J]. Chem. J. Chinese Universities, 1994, 15(8): 1168.
[11]	LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie. Synthesis and Drug Release Property of Biodegradable Polyphosphate Esters [J]. Chem. J. Chinese Universities, 1994, 15(6): 932.
[12]	LUO Yi, ZHUO Ren-xi, FAN Chang-Lie. Studies on the Synthesis and Antitumor Activity of Biodegradable Polyphosphamides [J]. Chem. J. Chinese Universities, 1994, 15(5): 767.
[13]	LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie. Synthesis and Antitumor Activity of Peptidyl-N¹-Hydroxymethyl-5-Fluorouracil [J]. Chem. J. Chinese Universities, 1994, 15(4): 545.
[14]	Zhuo Ren-xi, Liu Gao-wei, Peng Pu-ping . The Synthesis and Antitumor Activity of 5-Fluorouracil-N¹-Carbonyl Aminoacids and Oligopeptides [J]. Chem. J. Chinese Universities, 1991, 12(4): 555.
[15]	Zhao Rulin, Fan Changlie, Zhuo Renxi . Synthesis and Antitumor Activity of Amino Acid 5-Fluorouracil-1,3-dipropyl Esters Hydrochloride [J]. Chem. J. Chinese Universities, 1990, 11(5): 543.

Embedment and Deliverance of 5-Fluorouracil from Blended Membrane of Silk Fibroin and 5-Fluorouracil

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments